New PDF release: Amino Acid Neurotransmitters

By Ricardo Tapia (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)

ISBN-10: 1468431749

ISBN-13: 9781468431742

ISBN-10: 1468431765

ISBN-13: 9781468431766

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1973). Recently, data indicating a possible participation of the GABA mechanisms in other neurological disorders in human patients have been reported. McGeer et at. (1971) found that GAD activity was diminished in the substantia nigra and the globus pallidus of parkinsonism patients, and Lloyd and Hornykiewicz (1973) found that chronic treatment with L-dopa resulted in a return to normal GAD values in these structures. The possible participation of these factors in the well-known beneficial effect of L-dopa in PHARMACOLOGY OF GABA IN eNS 41 parkinsonism patients was mentioned by the latter authors.

And incubated for 20 min with GABA. Times of preincubation and incubation modified considerably the effects of aminooxyacetic acid. 'In cat spinal cord slices. 1 Reference Iversen and Johnston (1971), Johnston and Mitchell (1971) I versen and Johnston (1971), Johnston and Mitchell (1971) Iversen and Johnston (1971), Johnston and Mitchell (1971) Iversen and Johnston (1971), Johnston and Mitchell (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Iversen and Johnston (1971) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Beart and Johnston (1973) Bond (1973) Snodgrass and Iversen (1973) Snodgrass and Iversen (1973) Snodgrass and Iversen (1973) Gottesfeld and Elliott (1971) Gottesfeld and Elliott (1971) Balcar and Johnston (1973) Balcar and Johnston (1973) aRat brain slices unless otherwise indicated.

In some cases, perfusion chambers were used. The release was studied after the slices had been loaded with labeled GABA. The effects of amino acids normally present in brain tissue, which may be due to exchange, are not included in this table. 'Rat brain slices. , 1971). 'Hemisected frog spinal cords. 001 mM concentrations had no significant effect. electrically stimulated release seem to be related to the possible participation of Na+ transport in such spontaneous efflux, and of Na+jK+-ATPase in the electrically induced efflux (Hammerstad and Cutler, 1972 a).

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Amino Acid Neurotransmitters by Ricardo Tapia (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)


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