Cardiac Muscle: the Regulation of Excitation and Contraction - download pdf or read online

By Richard D. Nathan

ISBN-10: 0125143702

ISBN-13: 9780125143707

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M. Individual time constants are plotted for recovery from inactivation. The theoretical curves plotted in the figure were generated using Eqs. 00008 e x p ( - ( V - 5 ) / 1 7 ) . ] - 1 i0 l2 2 36 Robert S. Kass et al. A Β Fig. 5 . Calcium current (500-msec) inactivation in a calf Purkinje fiber after prepulses to positive potentials. Pulse protocol (inset): current was measured during a test pulse to 0 mV that had been preceded by 500-msec conditioning prepulses. A 10-msec return to the holding potential (—63 mV) separated prepulse from test pulse.

The relative contributions of various timedependent membrane currents to pacemaker activity in the sinoatrial node. In: "Cardiac Rate and Rhythm" (L. N. Bouman and H. J. ), pp. 5 3 - 6 8 . Martinus Nijhoff Publish­ ing, Boston. Brown, H. , Noble, D . , Noble, S. , and Taupignon, A. (1984a). The slow inward current, i , in the rabbit sino-atrial node investigated by voltage clamp and computer simula­ tion. Proc. R. Soc. London Β 222, 3 0 5 - 3 2 8 . Brown, H. , Noble, D . , Noble, S. , and Taupignon, A.

Kass et al. clamped ferret papillary muscle (Kanaya et al. 1983) and calf Purkinje fibers (Sanguinetti and Kass, 1984a). If drug-bound channels undergo voltage- and time-dependent transitions of state, the end result of a prolonged depolarization (or repeated depolarizations of sufficient duration) should be stabilization of channels in the drug-bound inactivated state. , 1984), shown below diagrammatically in a scheme first described by Hille (1977) for local anesthetic interaction with Na channels during a depolarizing event.

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Cardiac Muscle: the Regulation of Excitation and Contraction by Richard D. Nathan


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